After that, the fresh INTERSALT studies, hence documented a positive relationship involving the urinary Na + /K + ratio and you will blood pressure levels reported a loss of statistical need for the brand new relationship during the forty-two of your 52 centers once adjustment to own covariates also decades, gender and you may Bmi [thirty two, 33]
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in Match vs OkCupid cost SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The current investigation has several advantages: (1) Brand new Dashboard -Salt demonstration is a very carefully managed serving data and conformity try constantly monitored, (2) This new crossover build to possess Na + input greeting participant’s in order to serve as their particular control and you can diminished inter-individual variability, (3) 24-h ambulatory blood pressure levels recordings had been pulled, (4) lack of the brand new confounding effects of antihypertensive mediations, and (5) 24-h pee try range. The top restrict of one’s present investigation is the relatively smaller test dimensions which can has actually reduced all of our statistical capacity to locate more compact ramifications of urinary Na + , K + , and you will Na + :K + ratio with the SBP. Even as we didn’t to see an instability from inside the baseline characteristics, residual confounding within our analysis can be done.
A great multicenter data by the Suppa et al
To conclude the modern analysis of the Dashboard–Sodium Demo suggests that weight-loss K + supplements is not associated with the lower SBP and that the new decrease in SBP seen adopting the Dash weight loss intervention occurred alone regarding a reduced total of the new urinary Na + /K + excretion ratio despite the latest salt awareness regarding blood pressure level. Our data don’t hold the organization away from a-1:step 1 molar excretion proportion from Na + /K + because blood pressure decreasing means in Us Ebony and you can non-African People in the us and keep the DRI recommendation not to ever propose each and every day K + intake direction. Considering the restrictions of the latest study while the constant debate concerning your character regarding fat loss K + for the blood pressure levels coming carefully controlled studies are required to elucidate the possibility effect out-of weight-loss K + and you may urinary Na + /K + removal ratio to the blood pressure levels both in hypertensive and you will normotensive SS and you will SR participants.