step three.step three. Risk Things
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
Each other Bmi and you can lbs was indeed synchronised with BMD, and BMC signs and the strongest Pearson’s relationship coefficients was located ranging from lbs and BMC in total hip and you can trochanter nations and you may new weakest of those was basically anywhere between Body mass index and femoral neck BMC. The fresh correlations between age and you can BMD and BMC indicators was indeed negative (Dining table 4).
Age-adjusted ratio out-of BMD and you may BMC type told me by the Bmi and you will pounds is shown for the Table 5. Pounds tended to reveal greater differences in BMD and BMC shipment after all the new learned skeletal web sites as compared to Body mass index. It was shown of the steeper mountain (?) of your respective linear regression traces. Best difference between BMD and you may BMC delivery seemed during the trochanter BMC followed by lumbar BMC to possess weight. Lbs is an important predictor from BMD and you will BMC type into the older Iranian males.
4. Talk
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, bicupid thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
The components by which fatty tissue exerts positive effects towards the BMD updates aren’t totally obvious. The latest putative mechanism benefit regarding fat for skeletal integrity most likely resides in the part of a lot adipokines inside bones renovations owing to effect on one another creation and resorption. Has just, bone could have been experienced an enthusiastic hormonal body organ affecting body weight manage and you will sugar homoeostasis through the procedures out of limbs-derived factors like osteocalcin and you may osteopontin [23, 34–36]. This new putative crosstalk ranging from fat additionally the bones constitutes a good homoeostatic views system in which adipokines and you may particles secreted from the osteoblasts and you may osteoclasts depict the web link regarding a dynamic bones-adipose axis [34–36]. Carrying excess fat is also for the BMD because of the transformation of androgen in order to estrogen , hence improves bones mass in people [38, 39] and you will retains fit plasma quantities of insulin and you will regulating facts plus insulin-like increases factor-step one, leptin, and you can adiponectin . On the other hand, carrying excess fat provides padding for the cool in the event of a slide . However, brand new systems whereby all these events can be found continue to be unclear.