Of the need for blood circulation pressure since the a threat factor getting coronary arrest, i conducted analyses stratified from the history of blood pressure levels on standard
Neither access to potassium supplements (RR=0.78; 95% CI, 0.69 to at least one.22) neither entry to magnesium pills (RR=0.85; 95% CI, 0.55 to a single.32) was of this likelihood of overall or ischemic coronary attack during the analyses adjusted to possess age just, but access to potassium capsules turned into highly inversely related shortly after adjustment getting reputation for blood pressure (RR=0.55; 95% CI, 0.thirty-five to help you 0.86). History of blood pressure level is actually a robust independent chance basis getting coronary arrest (RR=dos.8; 95% CI, dos.step 1, 3.7) and you will are for the the means to access potassium products (46% of your 1248 enhance users had been hypertensives, compared to 19% away from nonusers). The brand new inverse organization anywhere between access to potassium medicine and you can risk of coronary arrest inside multivariate analyses try independent off dieting consumption out-of nutrients, including potassium, magnesium, and you can fiber, and you may try healthier one of boys that have lowest weight reduction consumption out-of potassium, magnesium, and you will cereal fiber. Brand new RR contrasting the major toward base quintile away from potassium intake was 0.39 throughout the lower tertile away from a diet rating, such as the step 3 nutrients married women seeking women, 0.57 between, and 0.86 in the large tertile. To further take to the fresh theory that use away from potassium tablets reduces the risk of coronary arrest, we compared boys just who stated using medications in 1986 and you can 1988 with guys whom never utilized pills. Inside the six kept years of realize-right up, new multivariate RR regarding full coronary arrest certainly enhance pages try 0.29 (95% CI, 0.a dozen, 0.85; P=0.02); the risk of stroke has also been faster among people exactly who advertised playing with potassium tablets merely in 1986 (0.46; 95% CI, 0.twenty-two, 0.98; P=0.05) but not certainly people who come bringing capsules for the 1988 (step 1.07; 95% CI, 0.55, 2.11).
Inverse relationships ranging from mineral intakes and you may threat of stroke have been noticed simply among hypertensive guys (Figures dos and you may step three ). During the analyses simply for men providing diuretics during the baseline, alone or in integration together with other antihypertensive medications, the fresh new RR out-of stroke getting users out-of potassium drugs compared to nonusers was 0.thirty-six (95% CI, 0.18, 0.72; P=0.004). One another fibre and you can cereal dietary fiber was in fact somewhat inversely in the exposure off heart attack certainly one of hypertensive (RRs to possess a 10-grams rise in intake were 0.59 and you may 0.33, respectively) however certainly normotensive (RRs was basically 0.88 both for) males.
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Inside highest prospective research, we found that guys with diets highest during the potassium, cereal fiber, and you can magnesium got a considerably smaller danger of coronary arrest. This type of inverse relationships had been merely partly told me by the nondietary exposure factors however, were good and tall only among men which have diagnosed blood pressure level. Zero extreme relationships was basically receive between intakes away from sodium and you may calcium and you will chance of coronary attack.
5 21 From inside the an excellent ong Japanese boys inside the Hawaii, potassium consumption is inversely connected with chance of fatal thromboembolic stroke (RR into the best versus the base quintile of consumption=0.3, P to have pattern=0.002) not having likelihood of nonfatal thromboembolic stroke (RR=0.87, P having trend=0.12). 2 New weakened relationship that have nonfatal events is not inconsistent having a defensive impact, having become diluted by error in the solitary twenty four-hour keep in mind– situated fat loss assessment. In the randomized examples, higher potassium intake possess brought about small reduction in blood pressure levels, particularly one of hypertensive victims. six eight That it impact, yet not, is smaller than average can simply partly give an explanation for solid inverse relationship noticed in this research. Likewise, modifications to have standard blood pressure level got absolutely nothing influence on new estimated RRs linked potassium consumption to coronary arrest incidence, and you can potassium intake wasn’t a serious predictor of threat of hypertension inside cohort. fourteen Choice systems advised are the inhibition away from free significant development, vascular easy muscle proliferation, and you may arterial thrombosis. 22 However, such outcomes were created by experimental grows into the serum potassium concentrations during the pet, and their value in order to people is unclear. Large potassium intake may increase gel levels, particularly when intake are reasonable or salt consumption is higher, twenty-two that will ergo reduce the danger of hypokalemia one of guys from the risky because of diuretic medication. Diuretic-triggered hypokalemia could raise the risk of ventricular dysrhythmia. 23 twenty-four No matter if no enhanced mortality of heart disease or other causes was located certainly one of people with lowest serum potassium in two previous knowledge, 25 twenty-six none are big enough in order to discover a certain association ranging from serum potassium and you may chance of heart attack.